1. <dd id="t14cv"><track id="t14cv"></track></dd>

        <button id="t14cv"><object id="t14cv"><input id="t14cv"></input></object></button>
        <dd id="t14cv"></dd>

        <rp id="t14cv"></rp>

      1. <rp id="t14cv"></rp>
      2. <dd id="t14cv"><pre id="t14cv"></pre></dd>

        <form id="t14cv"><tr id="t14cv"><kbd id="t14cv"></kbd></tr></form><em id="t14cv"><strike id="t14cv"><u id="t14cv"></u></strike></em>
        1. <nav id="t14cv"><sub id="t14cv"><address id="t14cv"></address></sub></nav>
          <th id="t14cv"></th>
            <dd id="t14cv"></dd>
                 
                 
                 
                 
                 
                副研究員

                閆明霞 副研究員
                副研究員,博士
                E-mail: mingxia_yan@126.com
                 

                      2000年畢業于佳木斯大學臨床醫學專業獲得臨床學士學位,2005年畢業于復旦大學動物學專業獲得理學碩士學位,2011年畢業于上海交通大學腫瘤學專業獲得腫瘤學博士學位。2005年7月-2018年5月就職于上海市腫瘤研究所,2018年6月起就職于復旦大學附屬腫瘤醫院,擔任腫瘤研究所實驗動物平臺主管。目前任上海市實驗動物學會理事,上海市實驗動物學會資源與設施專業委員會副主任委員,擔任《實驗動物與比較醫學》編委。工作以來主要從事腫瘤高轉移動物模型篩選及建立、腫瘤轉移相關分子機制等研究工作。以第一作者、通訊作者發表論文10余篇,參與發表論文20余篇;以第一責任人申請國家自然科學基金2項、上海市科委“創新行動計劃”等課題8項,總經費約300萬元,作為骨干參與國家“973”、國家十二五科技重大公關等課題研究;以第一發明人申請國家發明專利4項,參與申請5項,其中2項獲得專利授權。參編專業書籍2本,獲得上海醫學科技獎三等獎1項。


                研究領域:

                  腫瘤轉移的分子機制研究及抗腫瘤轉移的治療研究:
                  1. 腫瘤轉移動物模型的篩選及建立
                  2. 基于動物模型的抗腫瘤轉移治療研究
                  3. 腫瘤轉移的分子機制研究


                代表性論著:

                1.  Li Jing#, Cheng Dongdong#, Zhu Miaoxin, Yu Huajian, Pan Zhen, Liu Lei, Geng Qin, Pan Hongyu, Yan Mingxia*, Yao Ming*.OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Theranostics, 2019; 9(1):179–195.

                  metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2signaling pathway. Oncogene, 2015; 34:413-423.

                2. Chu D#, Li J#, Lin H, Zhang X, Pan H, Liu L, Yu T, Yan M*, Yao M*.Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.Oncol Lett., 2018; 15(6):9941–9952.

                3. Hechun Lin#, Xiao Zhang#, Li Liao, Tao Yu, Jing Li, Hongyu Pan, Lei Liu, Hanwei Kong, Lei Sun, Mingxia Yan*, Ming Yao*. CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation. J Cancer., 2018; 9(22):4215–4222.

                4. Dandan Chu#, Jing Li#, Hechun Lin, Xiao Zhang, Hongyu Pan, Lei Liu, Tao Yu, Mingxia Yan*, Ming Yao*. Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.OncolLett., 2018; 15(6):9941–9952.

                5. Yu T#, Zhao Y#, Hu Z, Li J, Chu D, Zhang J, Li Z, Chen B, Zhang X, Pan H, Li S, Lin H, Liu L, Yan M, He X*, Yao M*.MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.Cancer Res., 2017; 77(21):5782-5794.

                6. Wei Deng#, Mingxia Yan#, Tao Yu, Haiyan G, Hechun Lin, JingLi, Ying Liu, Qin Geng, Miaoxin Zhu, Lei Liu, Xianghuo He*, Ming Yao*. Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3pin non-small cell lung cancer.Cell PhysiolBiochem., 2015; 35:1677-1688.

                7. Cui YQ#, Geng Q, Yu T, Zhang FL, Lin HC, Li J, Zhu MX, Liu L, Yao M*, Yan MX*. Establishment of a highly metastatic model with a newly isolated lung adenocarcinoma cell line.Int JOncol., 2015; 47(3):927-940.

                8. Jing Li#, Tao Yu#, Jun Cao, Lei Liu, Ying Liu, Han-Wei Kong, Miao-Xin Zhu, He-Chun Lin, Dan-danChu, Ming Yao*, Ming-Xia Yan*.MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung Cancer. Cell PhysiolBiochem., 2015; 37:1847-1856.

                9. Mingxia Yan#, Hong Li, Miaoxin Zhu, Fangyu Zhao, Lixing Zhang, Taoyang Chen, Guoping Jiang, HaiyangXie, Ying Cui, Ming Yao, Jinjun Li*.GProtein-Coupled Receptor 87 (GPR87) promotes the growth and metastasis of CD133+ cancer stem-like cells in hepatocellular carcinoma. PLoS ONE, 2013; 8(4): e61056.

                10. Mingxia Yan#, Hong Li, Fangyu Zhao, Lixing Zhang, Chao Ge, Ming Yao, Jinjun Li*.Establishment of NOD/SCID mouse models of human hepatocellular carcinoma via subcutaneous transplantation of histologically intact tumor tissue. Chin J Cancer Res., 2013; 25(3): 289-298.

                11.  Tao Yu#, Jing Li, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Lei Sun, Yu Zhang, Yongqi Cui, Fanglin Zhang, Jinjun Li, Xianghuo He, Ming Yao*. MicroRNA-193a-3p and -5p suppress the

                 
                復旦大學腫瘤研究所 通訊地址: 東安路270號2號樓1312室 64175590-5312 Email:fuci2012@126.com
                Copyright 2013 shca.org.cn All rights reserved. 復旦大學腫瘤研究所 版權所有
                日本AV不卡在线观看无限看片 男女裸交真人全过程| 日本三级香港三级人妇三| 男人和女人做爽爽视频| 久久国产福利国产秒拍| 大香伊蕉在人线国产 视频| 免费国产A国产片高清| 免费大香伊蕉在人线国产| 婷婷丁香五月亚洲中文字幕| 中文无码久久精品| 色天天综合网视频网站| 日本不卡无码禁片免费大全|